4,371 research outputs found
Distributed Holistic Clustering on Linked Data
Link discovery is an active field of research to support data integration in
the Web of Data. Due to the huge size and number of available data sources,
efficient and effective link discovery is a very challenging task. Common
pairwise link discovery approaches do not scale to many sources with very large
entity sets. We here propose a distributed holistic approach to link many data
sources based on a clustering of entities that represent the same real-world
object. Our clustering approach provides a compact and fused representation of
entities, and can identify errors in existing links as well as many new links.
We support a distributed execution of the clustering approach to achieve faster
execution times and scalability for large real-world data sets. We provide a
novel gold standard for multi-source clustering, and evaluate our methods with
respect to effectiveness and efficiency for large data sets from the geographic
and music domains
Large Oligomeric Complex Structures Can Be Computationally Assembled by Efficiently Combining Docked Interfaces
Macromolecular oligomeric assemblies are involved in many biochemical processes of living organisms. The benefits of such assemblies in crowded cellular environments include increased reaction rates, efficient feedback regulation, cooperativity and protective functions. However, an atom‐level structural determination of large assemblies is challenging due to the size of the complex and the difference in binding affinities of the involved proteins. In this study, we propose a novel combinatorial greedy algorithm for assembling large oligomeric complexes from information on the approximate position of interaction interfaces of pairs of monomers in the complex. Prior information on complex symmetry is not required but rather the symmetry is inferred during assembly. We implement an efficient geometric score, the transformation match score, that bypasses the model ranking problems of state‐of‐the‐art scoring functions by scoring the similarity between the inferred dimers of the same monomer simultaneously with different binding partners in a (sub)complex with a set of pregenerated docking poses. We compiled a diverse benchmark set of 308 homo and heteromeric complexes containing 6 to 60 monomers. To explore the applicability of the method, we considered 48 sets of parameters and selected those three sets of parameters, for which the algorithm can correctly reconstruct the maximum number, namely 252 complexes (81.8%) in, at least one of the respective three runs. The crossvalidation coverage, that is, the mean fraction of correctly reconstructed benchmark complexes during crossvalidation, was 78.1%, which demonstrates the ability of the presented method to correctly reconstruct topology of a large variety of biological complexes. Proteins 2015; 83:1887–1899. © 2015 The Authors. Proteins: Structure, Function, and Bioinformatics Published by Wiley Periodicals, Inc
Declarative Choreographies and Liveness
Part 1: Full PapersInternational audienceWe provide the first formal model for declarative choreographies, which is able to express general omega-regular liveness properties. We use the Dynamic Condition Response (DCR) graphs notation for both choreographies and end-points. We define end-point projection as a restriction of DCR graphs and derive the condition for end-point projectability from the causal relationships of the graph. We illustrate the results with a running example of a Buyer-Seller-Shipper protocol. All the examples are available for simulation in the online DCR workbench at http://dcr.tools/forte19
Macbeth
analysis done 1998, revised 2002. Some scenes I would now characterise as extrusionsand I would switch Lady Macbeth's entrance in 2.2 to the inwards door. Despite Banquo's references in 2.1 that would place her elsewhere than Duncan's chambers, she now suddenly appears from there, having 'laid their daggers ready' (2.2.11). A surprise re-entrance as in Antony and Cleopatra 1.2
The dependence of intrinsic alignment of galaxies on wavelength using KiDS and GAMA
The outer regions of galaxies are more susceptible to the tidal interactions
that lead to intrinsic alignments of galaxies. The resulting alignment signal
may therefore depend on the passband if the colours of galaxies vary spatially.
To quantify this, we measured the shapes of galaxies with spectroscopic
redshifts from the GAMA survey using deep gri imaging data from the KiloDegree
Survey. The performance of the moment-based shape measurement algorithm DEIMOS
was assessed using dedicated image simulations, which showed that the
ellipticities could be determined with an accuracy better than 1% in all bands.
Additional tests for potential systematic errors did not reveal any issues. We
measure a significant difference of the alignment signal between the g,r and
i-band observations. This difference exceeds the amplitude of the linear
alignment model on scales below 2 Mpc/h. Separating the sample into
central/satellite and red/blue galaxies, we find that that the difference is
dominated by red satellite galaxies.Comment: 16 pages, 13 figures, accepted, to appear in A&
Feature Lines for Illustrating Medical Surface Models: Mathematical Background and Survey
This paper provides a tutorial and survey for a specific kind of illustrative
visualization technique: feature lines. We examine different feature line
methods. For this, we provide the differential geometry behind these concepts
and adapt this mathematical field to the discrete differential geometry. All
discrete differential geometry terms are explained for triangulated surface
meshes. These utilities serve as basis for the feature line methods. We provide
the reader with all knowledge to re-implement every feature line method.
Furthermore, we summarize the methods and suggest a guideline for which kind of
surface which feature line algorithm is best suited. Our work is motivated by,
but not restricted to, medical and biological surface models.Comment: 33 page
muCool: A novel low-energy muon beam for future precision experiments
Experiments with muons () and muonium atoms () offer
several promising possibilities for testing fundamental symmetries. Examples of
such experiments include search for muon electric dipole moment, measurement of
muon and experiments with muonium from laser spectroscopy to gravity
experiments. These experiments require high quality muon beams with small
transverse size and high intensity at low energy.
At the Paul Scherrer Institute, Switzerland, we are developing a novel device
that reduces the phase space of a standard beam by a factor of
with efficiency. The phase space compression is achieved by
stopping a standard beam in a cryogenic helium gas. The stopped
are manipulated into a small spot with complex electric and magnetic
fields in combination with gas density gradients. From here, the muons are
extracted into the vacuum and into a field-free region. Various aspects of this
compression scheme have been demonstrated. In this article the current status
will be reported.Comment: 8 pages, 5 figures, TCP 2018 conference proceeding
Are transnational tobacco companies' market access strategies linked to economic development models? A case study of South Korea.
Transnational tobacco companies (TTCs) have used varied strategies to access previously closed markets. Using TTCs' efforts to enter the South Korean market from the late 1980s as a case study, this article asks whether there are common patterns in these strategies that relate to the broader economic development models adopted by targeted countries. An analytical review of the existing literature on TTCs' efforts to access emerging markets was conducted to develop hypotheses relating TTCs' strategies to countries' economic development models. A case study of Korea was then undertaken based on analysis of internal tobacco industry documents. Findings were consistent with the hypothesis that TTCs' strategies in Korea were linked to Korea's export-oriented economic development model and its hostile attitude towards foreign investment. A fuller understanding of TTCs' strategies for expansion globally can be derived by locating them within the economic development models of specific countries or regions. Of foremost importance is the need for governments to carefully balance economic and public health policies when considering liberalisation
Neumark Operators and Sharp Reconstructions, the finite dimensional case
A commutative POV measure with real spectrum is characterized by the
existence of a PV measure (the sharp reconstruction of ) with real
spectrum such that can be interpreted as a randomization of . This paper
focuses on the relationships between this characterization of commutative POV
measures and Neumark's extension theorem. In particular, we show that in the
finite dimensional case there exists a relation between the Neumark operator
corresponding to the extension of and the sharp reconstruction of . The
relevance of this result to the theory of non-ideal quantum measurement and to
the definition of unsharpness is analyzed.Comment: 37 page
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